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Disease Profile

Sclerosing mucoepidermoid carcinoma with eosinophilia

Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.


US Estimated

Europe Estimated

Age of onset





Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.


Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.


dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.


recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.


Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.


Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.


Not applicable


Other names (AKA)



Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a type of cancer that most commonly affects the thyroid gland, but has been reported in the salivary gland as well.[1][2] Signs and symptoms include a painless neck mass.[2] Many people with mucoepidermoid carcinomas are women with Hashimoto's thyroiditis.[1][3] The prevalence of SMECE is unknown, but only around 50 cases have been described in the medical literature.[4] SMECE most commonly presents between 40 to 75 years of age.[2] SMECE was initially considered a "low-grade" tumor, however cases of SMECE spreading locally to lymph nodes and to distant organs have been described.[1][3] While data is limited, with treatment it appears that prognosis is typically good.[1][4][5][2]


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Organizations Supporting this Disease

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    These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

    In-Depth Information

    • PubMed is a searchable database of medical literature and lists journal articles that discuss Sclerosing mucoepidermoid carcinoma with eosinophilia. Click on the link to view a sample search on this topic.


      1. Kobayashi Y et al.,. Local recurrence of sclerosing mucoepidermoid carcinoma with eosinophilia in the upper lip: a case report. J Med Case Rep. 2015 Feb 24; 9:41. Accessed 5/20/2015.
      2. Frazier WD, Patel NP, Sullivan CA. Pathology quiz case 1. Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE). Arch Otolaryngol Head Neck Surg. 2008 Mar; 134(3):333, 335. Accessed 5/20/2015.
      3. Das S, Kalyani R. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid. Indian J Pathol Microbiol. 2008 Jan-Mar; 51(1):34-6. Accessed 5/20/2015.
      4. Quiroga-Garza G et al.,. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported. Hum Pathol. 2015 May; 46(5):725-31. Accessed 5/20/2015.
      5. Tasaki T et al.,. Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary gland: case report and review of the literature. Pathol Int. 2013 Feb; 63(2):125-31.